Full Text:   <1352>

Summary:  <674>

CLC number: 

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2022-10-13

Cited: 0

Clicked: 1395

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jian CHEN

https://orcid.org/0000-0002-2542-9669

Lie WANG

https://orcid.org/0000-0001-5094-012X

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Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.10 P.812-822

http://doi.org/10.1631/jzus.B2200174


Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes


Author(s):  Jing CHEN, Jian CHEN, Lie WANG

Affiliation(s):  Department of Gastrointestinal Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; more

Corresponding email(s):   wanglie@zju.edu.cn, zrchenjian@zju.edu.cn

Key Words:  Tertiary lymphoid structure (TLS), Tumor-infiltrating immunocyte, Tumor microenvironment (TME)



Abstract: 
Tertiary lymphoid structures (TLSs) are formations at sites with persistent inflammatory stimulation, including tumors. These ectopic lymphoid organs mainly consist of chemo-attracting B cells, T cells, and supporting dendritic cells (DCs). Mature TLSs exhibit functional organization for the optimal development and collaboration of adaptive immune response, delivering an augmented effect on the tumor microenvironment (TME). The description of the positive correlation between TLSs and tumor prognosis is reliable only under a certain condition involving the localization and maturation of TLSs. Emerging evidence suggests that underlying mechanisms of the anti-tumor effect of TLSs pave the way for novel immunotherapies. Several approaches have been developed to take advantage of intratumoral TLSs, either by combining it with therapeutic agents or by inducing the neogenesis of TLSs.

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