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On-line Access: 2019-08-21
Received: 2019-07-05
Revision Accepted: 2019-08-21
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Evaluation of L929 cell morphology on anthocyanin-containing gelatin-based hydrogel for early detection of infection
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Ghazal Shineh, Soheila S. Kordestani, Mohammadreza Tahriri, Lobat Tayebi. Evaluation of L929 cell morphology on anthocyanin-containing gelatin-based hydrogel for early detection of infection[J]. Journal of Zhejiang University Science D, 2019, 2(3): 181-186.
@article{title="Evaluation of L929 cell morphology on anthocyanin-containing gelatin-based hydrogel for early detection of infection",
author="Ghazal Shineh, Soheila S. Kordestani, Mohammadreza Tahriri, Lobat Tayebi",
journal="Journal of Zhejiang University Science D",
volume="2",
number="3",
pages="181-186",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-019-00047-6"
}
%0 Journal Article
%T Evaluation of L929 cell morphology on anthocyanin-containing gelatin-based hydrogel for early detection of infection
%A Ghazal Shineh
%A Soheila S. Kordestani
%A Mohammadreza Tahriri
%A Lobat Tayebi
%J Journal of Zhejiang University SCIENCE D
%V 2
%N 3
%P 181-186
%@ 1869-1951
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-019-00047-6
TY - JOUR
T1 - Evaluation of L929 cell morphology on anthocyanin-containing gelatin-based hydrogel for early detection of infection
A1 - Ghazal Shineh
A1 - Soheila S. Kordestani
A1 - Mohammadreza Tahriri
A1 - Lobat Tayebi
J0 - Journal of Zhejiang University Science D
VL - 2
IS - 3
SP - 181
EP - 186
%@ 1869-1951
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-019-00047-6
Abstract: Wounds heal through a complex process including four phases. Any interruption or interference in healing process can prevent wound healing. infection is one of the most common complications preventing wounds from healing. In this study, we investigated the fibroblast cell morphology and behavior of a gelatin-based hydrogel containing anthocyanin to determine whether it can be used for early detection of infection. The experimental results ascertained that 6 h after culturing the fibroblasts, they could be well attached to the surface of the hydrogel, and 48 h after seeding, they were spread over the surface and connected with each other. After the addition of a low dose of anthocyanin, the vitality of the cell increased, and the results of the ATR-FTIR analysis showed that anthocyanin could eliminate remaining glutaraldehyde free radicals. anthocyanin also could change its color after the addition of bacterial supernatant. Thus, hydrogels containing black carrot anthocyanin may be a potential therapeutic and diagnostic strategy to promote wound healing and early detection of infection.
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