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Journal of Zhejiang University SCIENCE A 2001 Vol.2 No.1 P.107~110

http://doi.org/10.1631/jzus.2001.0107


EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES


Author(s):  WANG Da, HE Chao, DING Wei, WANG Hui-ping

Affiliation(s):  First Affiliated Hospital,Medical College,Zhejiang University,Hangzhou 310003,China; more

Corresponding email(s): 

Key Words:  colorectal adenomas, TGF-&beta, 1, TGF-&beta, R II, immunohistochemistry


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WANG Da, HE Chao, DING Wei, WANG Hui-ping. EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES[J]. Journal of Zhejiang University Science A, 2001, 2(1): 107~110.

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author="WANG Da, HE Chao, DING Wei, WANG Hui-ping",
journal="Journal of Zhejiang University Science A",
volume="2",
number="1",
pages="107~110",
year="2001",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2001.0107"
}

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%T EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES
%A WANG Da
%A HE Chao
%A DING Wei
%A WANG Hui-ping
%J Journal of Zhejiang University SCIENCE A
%V 2
%N 1
%P 107~110
%@ 1869-1951
%D 2001
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2001.0107

TY - JOUR
T1 - EXPRESSION OF TGF-β1 AND TGF-β R II IN COLORECTAL ADENOMAS OF VARYING STAGES
A1 - WANG Da
A1 - HE Chao
A1 - DING Wei
A1 - WANG Hui-ping
J0 - Journal of Zhejiang University Science A
VL - 2
IS - 1
SP - 107
EP - 110
%@ 1869-1951
Y1 - 2001
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2001.0107


Abstract: 
To study the function of transforming growth factor β1 (TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-&beta;1) and transforming growth factor-β type II receptor (TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-&beta;r II) in varying stages of colorectal adenoma during neoplastic transformation, fifty-five cases of resected colorectal adenomas were examined immunohistochemically. Our results showed that the expression of TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-&beta;1 ranged from high to low, with the progression of low-grade to high-grade dysplasia of adenomas to carcinoma. And there was significantly different expression of TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-&beta;1 between moderate and high dysplasia adenomas (P<0.05), but no significantly different expression of TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-&beta; r II was found among varying stages of adenomas. Our results suggested that the quantities of TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-&beta;1 secreted by adenoma cells decrease dramatically in moderate to severe dysplasia colorectal adenomas. It is the decreased secretion of TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-&beta;1, rather than the mutated TGF-&beta%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>TGF-&beta;r II that may play an important role in transforming colorectal adenomas to adenocarcinomas.

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Reference

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