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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.7 P.515~521


Preimplantation genetic diagnosis for Down syndrome pregnancy

Author(s):  ZHANG Yu, XU Chen-ming, ZHU Yi-min, DONG Min-yue, QIAN Yu-li, JIN Fan, HUANG He-feng

Affiliation(s):  Department of Reproductive Endocrinology, Women’ more

Corresponding email(s):   huanghefg@hotmail.com

Key Words:  Down syndrome, Fluorescence in site hybridization (FISH), Preimplantation genetic diagnosis (PGD)

ZHANG Yu, XU Chen-ming, ZHU Yi-min, DONG Min-yue, QIAN Yu-li, JIN Fan, HUANG He-feng. Preimplantation genetic diagnosis for Down syndrome pregnancy[J]. Journal of Zhejiang University Science B, 2007, 8(7): 515~521.

@article{title="Preimplantation genetic diagnosis for Down syndrome pregnancy",
author="ZHANG Yu, XU Chen-ming, ZHU Yi-min, DONG Min-yue, QIAN Yu-li, JIN Fan, HUANG He-feng",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Preimplantation genetic diagnosis for Down syndrome pregnancy
%A XU Chen-ming
%A ZHU Yi-min
%A DONG Min-yue
%A QIAN Yu-li
%A JIN Fan
%A HUANG He-feng
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 7
%P 515~521
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0515

T1 - Preimplantation genetic diagnosis for Down syndrome pregnancy
A1 - XU Chen-ming
A1 - ZHU Yi-min
A1 - DONG Min-yue
A1 - QIAN Yu-li
A1 - JIN Fan
A1 - HUANG He-feng
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 7
SP - 515
EP - 521
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0515

Objective: To evaluate the effect of preimplantation genetic diagnosis (PGD) conducted for women who had down syndrome pregnancy previously. Methods: Trisomy 21 was diagnosed by using fluorescence in site hybridization (FISH) before embryo transfer in two women who had down syndrome pregnancies. Each received one or two PGD cycles respectively. Results: Case 1: one PGD cycle was conducted, two oocytes were fertilized and biopsied. One embryo is of trisomy 21 and the other of monosomy 21. No embryo was transferred. Case 2: two PGD cycles were conducted, in total, sixteen oocytes were fertilized and biopsied. Four embryos were tested to be normal, six of trisomy 21, and one of monosomy 21. Five had no signal. Four normal embryos were transferred but no pregnancy resulted. Conclusion: For couples who had pregnancies with down syndrome previously, PGD can be considered, and has been shown to be an effective strategy.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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