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CLC number: R741.05

On-line Access: 2012-05-04

Received: 2011-07-20

Revision Accepted: 2012-03-21

Crosschecked: 2012-04-11

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.5 P.395-401


Citric acid reduces the decline in P300 amplitude induced by acute alcohol consumption in healthy adults

Author(s):  Wei-xing Chen, Chuan-qin Xu, Shao-hua Chen, Gen-yun Xu, Huai-zhuang Ye

Affiliation(s):  Department of Gastroenterology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   chenweixing@hotmail.com

Key Words:  Ethanol, Citric acid, Event-related potential (ERP) P300, Cognitive function, Acetaldehyde

Wei-xing Chen, Chuan-qin Xu, Shao-hua Chen, Gen-yun Xu, Huai-zhuang Ye. Citric acid reduces the decline in P300 amplitude induced by acute alcohol consumption in healthy adults[J]. Journal of Zhejiang University Science B, 2012, 13(5): 395-401.

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author="Wei-xing Chen, Chuan-qin Xu, Shao-hua Chen, Gen-yun Xu, Huai-zhuang Ye",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Citric acid reduces the decline in P300 amplitude induced by acute alcohol consumption in healthy adults
%A Wei-xing Chen
%A Chuan-qin Xu
%A Shao-hua Chen
%A Gen-yun Xu
%A Huai-zhuang Ye
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 5
%P 395-401
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100230

T1 - Citric acid reduces the decline in P300 amplitude induced by acute alcohol consumption in healthy adults
A1 - Wei-xing Chen
A1 - Chuan-qin Xu
A1 - Shao-hua Chen
A1 - Gen-yun Xu
A1 - Huai-zhuang Ye
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 5
SP - 395
EP - 401
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100230

Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function during excessive alcohol consumption in healthy adults. Five volunteers were selected through clinical interview, physical examination, and psychiatric assessment for participation in this study. In a double-blind placebo-controlled before-after design, each subject was treated with 5 ml/kg body weight alcohol, 5 ml/kg body weight alcohol and 1 mg citric acid, or a placebo on three separate occasions, one week apart. ERP P300, blood biochemical indicators, blood alcohol concentrations (BACs) and acetaldehyde concentrations were assessed. Repeated measure analysis of variance (ANOVA) with a within-subjects factor was used to evaluate differences in blood biochemical indicators, BACs, blood acetaldehyde concentrations, and ERP P300 in the three sessions of assessments. Several blood biochemical indicators showed significant differences between treatments, including the levels of cholinesterase (CHE), total bile acid (TBA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and glycylproline dipeptidyl aminopeptidase (GPDA). BACs after consumption of alcohol alone or citric acid with alcohol were significantly higher compared to those after placebo treatment (P<0.05). There were no significant differences in blood acetaldehyde concentrations between the treatments. The P300 amplitudes on the frontal (Fz), central (Cz), and parietal (Pz) regions of the scalp after consumption of alcohol were significantly lower than those after consumption of the placebo or citric acid with alcohol (P<0.05), while there were no significant differences between the latter two treatments. The results of this study suggest that citric acid could reduce the decline in ERP P300 amplitude and cognitive ability induced by acute alcohol consumption. It may also affect some blood biochemical indicators, but the specific mechanisms need further research.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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