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Received: 2013-05-13

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.8 P.688-695

10.1631/jzus.B1300137


Metabolic remodeling in chronic heart failure


Author(s):  Jing Wang, Tao Guo

Affiliation(s):  Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

Corresponding email(s):   guotao20@hotmail.com

Key Words:  Chronic heart failure (CHF), Metabolic remodeling, Metabolic substrate, Metabolic capability


Jing Wang, Tao Guo. Metabolic remodeling in chronic heart failure[J]. Journal of Zhejiang University Science B, 2013, 14(8): 688-695.

@article{title="Metabolic remodeling in chronic heart failure",
author="Jing Wang, Tao Guo",
journal="Journal of Zhejiang University Science B",
volume="14",
number="8",
pages="688-695",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1300137"
}

%0 Journal Article
%T Metabolic remodeling in chronic heart failure
%A Jing Wang
%A Tao Guo
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 8
%P 688-695
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300137

TY - JOUR
T1 - Metabolic remodeling in chronic heart failure
A1 - Jing Wang
A1 - Tao Guo
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 8
SP - 688
EP - 695
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300137


Abstract: 
Although the management of chronic heart failure (CHF) has made enormous progress over the past decades, CHF is still a tremendous medical and societal burden. metabolic remodeling might play a crucial role in the pathophysiology of CHF. The characteristics and mechanisms of metabolic remodeling remained unclear, and the main hypothesis might include the changes in the availability of metabolic substrate and the decline of metabolic capability. In the early phases of the disease, metabolism shifts toward carbohydrate utilization from fatty acids (FAs) oxidation. Along with the progress of the disease, the increasing level of the hyperadrenergic state and insulin resistance cause the changes that shift back to a greater FA uptake and oxidation. In addition, a growing body of experimental and clinical evidence suggests that the improvement in the metabolic capability is likely to be more significant than the selection of the substrate.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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