Full Text:   <1508>

Summary:  <1103>

CLC number: Q291

On-line Access: 2013-12-03

Received: 2013-08-14

Revision Accepted: 2013-11-21

Crosschecked: 2013-11-21

Cited: 9

Clicked: 3007

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.12 P.1059-1069

http://doi.org/10.1631/jzus.B1300215


Induced pluripotent stem cells: origins, applications, and future perspectives


Author(s):  Jing Zhao, Wen-jie Jiang, Chen Sun, Cong-zhe Hou, Xiao-mei Yang, Jian-gang Gao

Affiliation(s):  School of Life Sciences, Shandong University, Jinan 250100, China

Corresponding email(s):   yxm411@sdu.edu.cn, jggao@sdu.edu.cn

Key Words:  Induced pluripotent stem cells, Origin, Peripheral blood cells, Application, Potential issues


Share this article to: More |Next Article >>>

Jing Zhao, Wen-jie Jiang, Chen Sun, Cong-zhe Hou, Xiao-mei Yang, Jian-gang Gao. Induced pluripotent stem cells: origins, applications, and future perspectives[J]. Journal of Zhejiang University Science B, 2013, 14(12): 1059-1069.

@article{title="Induced pluripotent stem cells: origins, applications, and future perspectives",
author="Jing Zhao, Wen-jie Jiang, Chen Sun, Cong-zhe Hou, Xiao-mei Yang, Jian-gang Gao",
journal="Journal of Zhejiang University Science B",
volume="14",
number="12",
pages="1059-1069",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1300215"
}

%0 Journal Article
%T Induced pluripotent stem cells: origins, applications, and future perspectives
%A Jing Zhao
%A Wen-jie Jiang
%A Chen Sun
%A Cong-zhe Hou
%A Xiao-mei Yang
%A Jian-gang Gao
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 12
%P 1059-1069
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300215

TY - JOUR
T1 - Induced pluripotent stem cells: origins, applications, and future perspectives
A1 - Jing Zhao
A1 - Wen-jie Jiang
A1 - Chen Sun
A1 - Cong-zhe Hou
A1 - Xiao-mei Yang
A1 - Jian-gang Gao
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 12
SP - 1059
EP - 1069
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300215


Abstract: 
Embryonic stem (ES) cells are widely used for different purposes, including gene targeting, cell therapy, tissue repair, organ regeneration, and so on. However, studies and applications of ES cells are hindered by ethical issues regarding cell sources. To circumvent ethical disputes, great efforts have been taken to generate ES cell-like cells, which are not derived from the inner cell mass of blastocyst-stage embryos. In 2006, Yamanaka et al. first reprogrammed mouse embryonic fibroblasts into ES cell-like cells called induced pluripotent stem (iPS) cells. About one year later, Yamanaka et al. and Thomson et al. independently reprogrammed human somatic cells into iPS cells. Since the first generation of iPS cells, they have now been derived from quite a few different kinds of cell types. In particular, the use of peripheral blood facilitates research on iPS cells because of safety, easy availability, and plenty of cell sources. Now iPS cells have been used for cell therapy, disease modeling, and drug discovery. In this review, we describe the generations, applications, potential issues, and future perspectives of iPS cells.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Aasen, T., Raya, A., Barrero, M.J., Garreta, E., Consiglio, A., Gonzalez, F., Vassena, R., Bilić, J., Pekarik, V., Tiscornia, G., et al., 2008. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat. Biotechnol., 26(11):1276-1284.

[2]Anokye-Danso, F., Trivedi, C.M., Juhr, D., Gupta, M., Cui, Z., Tian, Y., Zhang, Y., Yang, W., Gruber, P.J., Epstein, J.A., et al., 2011. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell, 8(4):376-388.

[3]Aoi, T., Yae, K., Nakagawa, M., Ichisaka, T., Okita, K., Takahashi, K., Chiba, T., Yamanaka, S., 2008. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science, 321(5889):699-702.

[4]Aoki, T., Ohnishi, H., Oda, Y., Tadokoro, M., Sasao, M., Kato, H., Hattori, K., Ohgushi, H., 2010. Generation of induced pluripotent stem cells from human adipose-derived stem cells without c-Myc. Tissue Eng. Part A, 16(7):2197-206.

[5]Carvajal-Vergara, X., Sevilla, A., D′Souza, S.L., Ang, Y.S., Schaniel, C., Lee, D.F., Yang, L., Kaplan, A.D., Adler, E.D., Rozov, R., et al., 2010. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature, 465(7299):808-812.

[6]Chang, M.Y., Kim, D., Kim, C.H., Kang, H.C., Yang, E., Moon, J.I., Ko, S., Park, J., Park, K.S., Lee, K.A., et al., 2010. Direct reprogramming of rat neural precursors cells and fibroblasts into pluripotent stem cells. PLoS ONE, 5(3):e9838.

[7]Chesné, P., Adenot, P.G., Viglietta, C., Baratte, M., Boulanger, L., Renard, J.P., 2002. Cloned rabbits produced by nuclear transfer from adult somatic cells. Nat. Biotechnol., 20(4):366-369.

[8]Cho, H.J., Lee, C.S., Kwon, Y.W., Paek, J.S., Lee, S.H., Hur, J., Lee, E.J., Roh, T.Y., Chu, I.S., Leem, S.H., et al., 2010. Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation. Blood, 116(3):386-395.

[9]Chou, B.K., Mali, P., Huang, X., Ye, Z., Dowey, S.N., Resar, L.M., Zou, C., Zhang, Y.A., Tong, J., Cheng, L., 2011. Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res., 21(3):518-529.

[10]Desponts, C., Ding, S., 2010. Using small molecules to improve generation of induced pluripotent stem cells from somatic cells. Methods Mol. Biol., 636:207-218.

[11]Dimos, J.T., Rodolfa, K.T., Niakan, K.K., Weisenthal, L.M., Mitsumoto, H., Chung, W., Croft, G.F., Saphier, G., Leibel, R., Goland, R., et al., 2008. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science, 321(5893):1218-1221.

[12]Easley, C.A.4th, Phillips, B.T., McGuire, M.M., Barringer, J.M., Valli, H., Hermann, B.P., Simerly, C.R., Rajkovic, A., Miki, T., Orwig, K.E., et al., 2012. Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Rep., 2(3):440-446.

[13]Ebert, A.D., Yu, J.Y., Rose, F.F., Mattis, V.B., Lorson, C.L., Thomson, J.A., Svendsen, C.N., 2009. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature, 457(7227):277-280.

[14]Ebihara, Y., Ma, F., Tsuji, K., 2012. Generation of red blood cells from human embryonic/induced pluripotent stem cells for blood transfusion. Int. J. Hematol., 95(6):610-616.

[15]Eminli, S., Foudi, A., Stadtfeld, M., Maherali, N., Ahfeldt, T., Mostoslavsky, G., Hock, H., Hochedlinger, K., 2009. Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat. Genet., 41(9):968-976.

[16]Evans, M.J., Kaufman, M.H., 1981. Establishment in culture of pluripotent cells from mouse embryos. Nature, 292(5819):154-156.

[17]Feng, B., Jiang, J., Kraus, P., Ng, J.H., Heng, J.C., Chan, Y.S., Yaw, L.P., Zhang, W., Loh, Y.H., Han, J., et al., 2009. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat. Cell Biol., 11(2):197-203.

[18]Fusaki, N., Ban, H., Nishiyama, A., Saeki, K., Hasegawa, M., 2009. Efficient induction of transgene free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci., 85(8):348-362.

[19]Giorgetti, A., Montserrat, N., Aasen, T., Gonzalez, F., Rodríguez-Pizà, I., Vassena, R., Raya, A., Boué, S., Barrero, M.J., Corbella, B.A., et al., 2009. Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell, 5(4):353-357.

[20]Gore, A., Li, A., Fung, H.L., Young, J.E., Agarwal, S., Antosiewicz-Bourget, J., Canto, I., Giorgetti, A., Israel, M.A., Kiskinis, E., et al., 2011. Somatic coding mutations in human induced pluripotent stem cells. Nature, 471(7336):63-67.

[21]Gurdon, J.B., 1962. The development capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. Embryol. Exp. Morphol., 10(4):622-640.

[22]Haase, A., Olmer, R., Schwanke, K., Wunderlich, S., Merkert, S., Hess, C., Zweigerdt, R., Gruh, I., Meyer, J., Wagner, S., et al., 2009. Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell, 5(4):434-441.

[23]Hanna, J., Wernig, M., Markoulaki, S., Sun, C.W., Meissner, A., Cassady, J.P., Beard, C., Brambrink, T., Wu, L.C., Townes, T.M., et al., 2007. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science, 318(5858):1920-1923.

[24]Hanna, J., Markoulaki, S., Schorderet, P., Carey, B.W., Beard, C., Wernig, M., Creyghton, M.P., Steine, E.J., Cassady, J.P., Foreman, R., et al., 2008. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell, 133(2):250-264.

[25]Heng, J.C., Feng, B., Han, J., Jiang, J., Kraus, P., Ng, J.H., Orlov, Y.L., Huss, M., Yang, L., Lufkin, T., et al., 2010. The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell, 6(2):167-174.

[26]Honda, A., Hirose, M., Hatori, M., Matoba, S., Miyoshi, H., Inoue, K., Ogura, A., 2010. Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine. J. Biol. Chem., 285(41):31362-31369.

[27]Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., Yamanaka, S., 2009. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature, 460(7259):1132-1135.

[28]Hotta, A., Cheung, A.Y., Farra, N., Vijayaragavan, K., Séguin, C.A., Draper, J.S., Pasceri, P., Maksakova, I.A., Mager, D.L., Rossant, J., et al., 2009. Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency. Nat. Methods, 6(5):370-376.

[29]Hou, P.P., Li, Y.Q., Zhang, X., Liu, C., Guan, J.Y., Li, H.G., Zhao, T., Ye, J.Q., Zhao, Y., Deng, H.K., 2013. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science, 341(6146):651-654.

[30]Huangfu, D., Osafune, K., Maehr, R., Guo, W., Eijkelenboom, A., Chen, S., Muhlestein, W., Melton, D.A., 2008. Melton induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat. Biotechnol., 26(11):1269-1275.

[31]Kaji, K., Norrby, K., Paca, A., Mileikovsky, M., Mohseni, P., Woltjen, K., 2009. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature, 458(7239):771-775.

[32]Kang, L., Wang, J., Zhang, Y., Kou, Z., Gao, S., 2009. iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell, 5(2):135-138.

[33]Kim, D., Kim, C.H., Moon, J.I., Chung, Y.G., Chang, M.Y., Han, B.S., Yang, E., Cha, K.Y., Lanza, R., Kim, K.S., 2009. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell, 4(6):472-476.

[34]Kim, J.B., Zaehres, H., Wu, G., Gentile, L., Ko, K., Sebastiano, V., Araúzo-Bravo, M.J., Ruau, D., Han, D.W., Zenke, M., et al., 2008. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature, 454(7204):646-650.

[35]Kim, J.B., Greber, B., Araúzo-Bravo, M.J., Meyer, J., Park, K.I., Zaehres, H., Schöler, H.R., 2009a. Direct reprogramming of human neural stem cells by OCT4. Nature, 461(7264):649-653.

[36]Kim, J.B., Sebastiano, V., Wu, G., Araúzo-Bravo, M.J., Sasse, P., Gentile, L., Ko, K., Ruau, D., Ehrich, M., van den Boom, D., et al., 2009b. Oct4-induced pluripotency in adult neural stem cells. Cell, 136(3):411-419.

[37]Lacoste, A., Berenshteyn, F., Brivanlou, A.H., 2009. An efficient and reversible transposable system for gene delivery and lineage-specific differentiation in human embryonic stem cells. Cell Stem Cell, 5(3):332-342.

[38]Lagarkova, M.A., Shutova, M.V., Bogomazova, A.N., Vassina, E.M., Glazov, E.A., Zhang, P., Rizvanov, A.A., Chestkov, I.V., Kiselev, S.L., 2010. Induction of pluripotency in human endothelial cells resets epigenetic profile on genome scale. Cell Cycle, 9(5):937-946.

[39]Lee, G., Papapetrou, E.P., Kim, H., Chambers, S.M., Tomishima, M.J., Fasano, C.A., Ganat, Y.M., Menon, J., Shimizu, F., Viale, A., et al., 2009. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPS cells. Nature, 461(7262):402-406.

[40]Lei, F., Haque, R., Xiong, X., Song, J., 2012. Directed differentiation of induced pluripotent stem cells towards T lymphocytes. J. Vis. Exp., 63:e3986.

[41]Li, C., Zhou, J., Shi, G., Ma, Y., Yang, Y., Gu, J., Yu, H., Jin, S., Wei, Z., Chen, F., et al., 2009. Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells. Hum. Mol. Genet., 18(22):4340-4349.

[42]Li, W., Ding, S., 2010. Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends Pharmacol. Sci., 31(1):36-45.

[43]Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., Hao, E., Hayek, A., Deng, H., Ding, S., 2009. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell, 4(1):16-19.

[44]Liao, J., Cui, C., Chen, S., Ren, J., Chen, J., Gao, Y., Li, H., Jia, N., Cheng, L., Xiao, H., et al., 2009. Generation of induced pluripotent stem cell lines from adult rat cells. Cell Stem Cell, 4(1):11-15.

[45]Liu, H., Zhu, F., Yong, J., Zhang, P., Hou, P., Li, H., Jiang, W., Cai, J., Liu, M., Cui, K., et al., 2008. Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. Cell Stem Cell, 3(6):587-590.

[46]Liu, H., Ye, Z., Sharkis, S., Jang, Y.Y., 2010. Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes. Hepatology, 51(5):1810-1819.

[47]Loh, Y.H., Hartung, O., Li, H., Guo, C., Sahalie, J.M., Manos, P.D., Urbach, A., Heffner, G.C., Grskovic, M., Vigneault, F., et al., 2010. Reprogramming of T cells from human peripheral blood. Cell Stem Cell, 7(1):15-19.

[48]Maehr, R., Chen, S., Snitow, M., Ludwig, T., Yagasaki, L., Goland, R., Leibel, R.L., Melton, D.A., 2009. Generation of pluripotent stem cells from patients with type 1 diabetes. PNAS, 106(37):15768-15773.

[49]Maherali, N., Sridharan, R., Xie, W., Utikal, J., Eminli, S., Arnold, K., Stadtfeld, M., Yachechko, R., Tchieu, J., Jaenisch, R., et al., 2007. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell, 1(1):55-70.

[50]Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., Yamanaka, S., 2008. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol., 26(1):101-106.

[51]Nishimura, K., Sano, M., Ohtaka, M., Furuta, B., Umemura, Y., Nakajima, Y., Ikehara, Y., Kobayashi, T., Segawa, H., Takayasu, S., et al., 2010. Development of defective and persistent sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming. J. Biol. Chem., 286(6):4760-4771.

[52]Okita, K., Ichisaka, T., Yamanaka, S., 2007. Generation of germline-competent induced pluripotent stem cells. Nature, 448(7151):313-317.

[53]Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., Yamanaka, S., 2008. Generation of mouse induced pluripotent stem cells without viral vectors. Science, 322(5903):949-953.

[54]Okita, K., Matsumura, Y., Sato, Y., Okada, A., Morizane, A., Okamoto, S., Hong, H., Nakagawa, M., Tanabe, K., Tezuka, K., et al., 2011. A more efficient method to generate integration-free human iPS cells. Nat. Methods, 8(5):409-412.

[55]Park, I.H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A., Lensch, M.W., Cowan, C., Hochedlinger, K., Daley, G.Q., 2008. Disease-specific induced pluripotent stem cells. Cell, 134(5):877-886.

[56]Ruiz, S., Brennand, K., Panopoulos, A.D., Herrerías, A., Gage, F.H., Izpisua-Belmonte, J.C., 2010. High-efficient generation of induced pluripotent stem cells from human astrocytes. PLoS ONE, 5(12):e15526.

[57]Seki, T., Yuasa, S., Oda, M., Eqashira, T., Yae, K., Kusumoto, D., Nakata, H., Tohyama, S., Hashimoto, H., Kodaira, M., et al., 2010. Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells. Cell Stem Cell, 7(1):11-14.

[58]Si-Tayeb, K., Noto, F.K., Sepac, A., Sedlic, F., Bosnjak, Z.J., Lough, J.W., Duncan, S.A., 2010. Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors. BMC Dev. Biol., 10(1):81.

[59]Soldner, F., Hockemeyer, D., Beard, C., Gao, Q., Bell, G.W., Cook, E.G., Hargus, G., Blak, A., Cooper, O., Mitalipova, M., et al., 2009. Parkinson’s disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell, 136(5):964-977.

[60]Stadtfeld, M., Hochedlinger, K., 2010. Induced pluripotency: history, mechanisms, and applications. Genes Dev., 24(20):2239-2263.

[61]Stadtfeld, M., Nagaya, M., Utikal, J., Weir, G., Hochedlinger, K., 2008a. Induced pluripotent stem cells generated without viral integration. Science, 322(5903):945-949.

[62]Stadtfeld, M., Brennand, K., Hochedlinger, K., 2008b. Reprogramming of pancreatic β cells into induced pluripotent stem cells. Curr. Biol., 18(12):890-894.

[63]Staerk, J., Dawlaty, M.M., Gao, Q., Maetzel, D., Hanna, J., Sommer, C.A., Mostoslavsky, G., Jaenisch, R., 2010. Reprogramming of human peripheral blood cells to induced pluripotent stem cells. Cell Stem Cell, 7(1):20-24.

[64]Sugii, S., Kida, Y., Kawamura, T., Suzuki, J., Vassena, R., Yin, Y.Q., Lutz, M.K., Berggren, W.T., Izpisúa Belmonte, J.C., Evans, R.M., 2010. Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. PNAS, 107(8):3558-3563.

[65]Sun, N., Panetta, N.J., Gupta, D.M., Wilson, K.D., Lee, A., Jia, F., Hu, S., Cherry, A.M., Robbins, R.C., Longaker, M.T., et al., 2009. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. PNAS, 106(37):15720-15725.

[66]Takahashi, K., Yamanaka, S., 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4):663-676.

[67]Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., Yamanaka, S., 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5):861-872.

[68]Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swierqiel, J.J., Marshall, V.S., Jones, J.M., 1998. Embryonic stem cell lines derived from human blastocysts. Science, 282(5391):1145-1147.

[69]Tsai, S.Y., Clavel, C., Kim, S., Ang, Y.S., Grisanti, L., Lee, D.F., Kelley, K., Rendl, M., 2010. Oct4 and klf4 reprogram dermal papilla cells into induced pluripotent stem cells. Stem Cells, 28(2):221-228.

[70]Utikal, J., Maherali, N., Kulalert, W., Hochedlinger, K., 2009. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J. Cell Sci., 122(19):3502-3510.

[71]Warren, L., Manos, P.D., Ahfeldt, T., Loh, Y.H., Li, H., Lau, F., Ebina, W., Mandal, P.K., Smith, Z.D., Meissner, A., et al., 2010. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell, 7(5):618-630.

[72]Wernig, M., Meissner, A., Foreman, R., Brambrink, T., Ku, M., Hochedlinger, K., Bernstein, B.E., Jaenisch, R., 2007. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature, 448(7151):318-324.

[73]Wernig, M., Lengner, C.J., Hanna, J., Lodato, M.A., Steine, E., Foreman, R., Staerk, J., Markoulaki, S., Jaenisch, R., 2008. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat. Biotechnol., 26(8):916-924.

[74]Wilmut, I., Schnieke, A.E., McWhir, J., Kind, A.J., Campbell, K.H., 1997. Viable offspring derived from fetal and adult mammalian cells. Nature, 385(6619):810-813.

[75]Woltjen, K., Michael, I.P., Mohseni, P., Desai, R., Mileikovsky, M., Hämäläinen, R., Cowling, R., Wang, W., Liu, P., Gertsenstein, M., et al., 2009. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature, 458(7239):766-770.

[76]Wu, Y., Zhang, Y., Mishra, A., Tardif, S.D., Hornsby, P.J., 2010. Generation of induced pluripotent stem cells from newborn marmoset skin fibroblasts. Stem Cell Res., 4(3):180-188.

[77]Wu, Z., Chen, J., Ren, J., Bao, L., Liao, J., Cui, C., Rao, L., Li, H., Gu, Y., Dai, H., et al., 2009. Generation of pig induced pluripotent stem cells with a drug-inducible system. J. Mol. Cell Biol., 1(1):46-54.

[78]Yakubov, E., Rechavi, G., Rozenblatt, S., Givol, D., 2010. Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors. Biochem. Biophys. Res. Commun., 394(1):189-193.

[79]Yamanaka, S., 2012. Induced pluripotent stem cells: past, present, and future. Cell Stem Cell, 10(6):678-684.

[80]Ye, L., Chang, J.C., Lin, C., Sun, X., Yu, J., Kan, Y.W., 2009. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. PNAS, 106(24):9826-9830.

[81]Ye, Z., Zhan, H., Mali, P., Dowey, S., Williams, D.M., Jang, Y.Y., Dang, V.L., Spivak, J.L., Moliterno, A.R., Cheng, L., 2009. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood, 114(27):5473-5480.

[82]Ying, Q.L., Nichols, J., Evans, E.P., Smith, A.G., 2002. Changing potency by spontaneous fusion. Nature, 416(6880):545-548.

[83]Yu, J., Vodyanik, M.K., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J.L., Tian, S., Nie, J., Jonsdottir, G.A., Ruotti, V., Stewart, R., et al., 2007. Induced pluripotent stem cell lines derived from human somatic cells. Science, 318(5858):1917-1920.

[84]Yu, J., Hu, K., Smuga-Otto, K., Tian, S., Stewart, R., Slukvin, I.I., Thomson, J.A., 2009. Human induced pluripotent stem cells free of vector and transgene sequences. Science, 324(5928):797-801.

[85]Zhang, J., Zhao, J., Jiang, W.J., Shan, X.W., Yang, X.M., Gao, J.G., 2012. Conditional gene manipulation: Cre-ating a new biological ear. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 13(7):511-524.]

[86]Zhao, H.X., Li, Y., Jin, H.F., Xie, L., Liu, C., Jiang, F., Luo, Y.N., Yin, G.W., Li, Y., Wang, J., et al., 2010. Rapid and efficient reprogramming of human amnion-derived cells into pluripotency by three factors OCT4/SOX2/NANOG. Differentiation, 80(2-3):123-129.

[87]Zhao, X.Y., Li, W., Lv, Z., Liu, L., Tong, M., Hai, T., Hao, J., Guo, C.L., Ma, Q.W., Wang, L., et al., 2009. iPS cells produce viable mice through tetraploid complementation. Nature, 461(7260):86-90.

[88]Zhou, H., Wu, S., Joo, J.Y., Zhu, S., Han, D.W., Lin, T., Trauger, S., Bien, G., Yao, S., Zhu, Y., et al., 2009. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell, 4(5):381-384.

[89]Zhou, W., Freed, C.R., 2009. Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells. Stem Cells, 27(11):2667-2674.

[90]Zhu, Y., Hu, H.L., Li, P., Yang, S., Zhang, W., Ding, H., Tian, R.H., Ning, Y., Zhang, L.L., Guo, X.Z., et al., 2012. Generation of male germ cells from induced pluripotent stem cells (iPS cells): an in vitro and in vivo study. Asian J. Androl., 14(4):574-579.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - Journal of Zhejiang University-SCIENCE