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CLC number: R979.1+4

On-line Access: 2017-01-03

Received: 2016-08-10

Revision Accepted: 2016-10-05

Crosschecked: 2016-12-12

Cited: 2

Clicked: 2420

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xi-ping Zhang

http://orcid.org/0000-0002-3556-9681

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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.1 P.15-26

http://doi.org/10.1631/jzus.B1600303


Use of liposomal doxorubicin for adjuvant chemotherapy of breast cancer in clinical practice


Author(s):  Ming Zhao, Xian-feng Ding, Jian-yu Shen, Xi-ping Zhang, Xiao-wen Ding, Bin Xu

Affiliation(s):  College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China; more

Corresponding email(s):   zxp99688@sina.com, 626876448@qq.com

Key Words:  Liposomal doxorubicin, Toxic and side effects, Breast cancer, Adjuvant chemotherapy, Therapeutic effect, Toxic and side effects


Ming Zhao, Xian-feng Ding, Jian-yu Shen, Xi-ping Zhang, Xiao-wen Ding, Bin Xu. Use of liposomal doxorubicin for adjuvant chemotherapy of breast cancer in clinical practice[J]. Journal of Zhejiang University Science B, 2017, 18(1): 15-26.

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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600303"
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A1 - Xian-feng Ding
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DOI - 10.1631/jzus.B1600303


Abstract: 
breast cancer is one of the malignant tumors with the highest morbidity and mortality. It is helpful to reduce the rate of tumor recurrence and metastasis by treating breast cancer with adjuvant chemotherapy, so as to increase the cure rate or survival of patients. In recent years, liposomes have been regarded as a kind of new carrier for targeted drugs. Being effective for enhancing drug efficacy and reducing side effects, they have been widely used for developing anticancer drugs. As a kind of anthracycline with high anticancer activity, doxorubicin can treat or alleviate a variety of malignant tumors effectively when it is used on its own or in combination with other anticancer drugs. Although liposomal doxorubicin has been extensively used in the adjuvant chemotherapy of breast cancer, its exact therapeutic efficacy and side effects have not been definitely proven. Various clinical studies have adopted different combined regimes, dosages, and staging, so their findings differ to certain extent. This paper reviews the clinical application of liposomal doxorubicin in the adjuvant chemotherapy of breast cancer and illustrates therapeutic effects and side effects of pegylated liposomal doxorubicin (PLD) and non-PLD (NPLD) in clinical research, in order to discuss the strategies for applying these drugs in such adjuvant chemotherapy, looking forward to providing references for related research and clinical treatment in terms of dosage, staging, combined regimes, and analysis methods and so on.

多柔比星脂质体在乳腺癌辅助化疗中的临床应用

概要:通过综述多柔比星脂质体在乳腺癌辅助化疗中的临床应用,分别阐述临床研究中聚乙二醇多柔比星脂质体(PLD)与非聚乙二醇多柔比星脂质体(NPLD)的治疗效果及毒副作用。进而探讨其在乳腺癌辅助化疗中的使用策略,在用药剂量、分期、联合方案及分析方法等方面,为相关研究及临床治疗提供有价值的参考。
关键词:多柔比星脂质体;乳腺癌;辅助化疗;疗效;毒副作用

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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