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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.10 P.740~747

10.1631/jzus.B0920119


Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane


Author(s):  Xing TAO, Ling-qiao LU, Qing XU, Shu-ren LI, Mao-tsun LIN

Affiliation(s):  Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100069, China; more

Corresponding email(s):   CSA8@china.com, 891201@mail.chimei.org.tw

Key Words:  Anesthetic, Heart, Propofol, Isoflurane, Apoptosis


Xing TAO, Ling-qiao LU, Qing XU, Shu-ren LI, Mao-tsun LIN. Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane[J]. Journal of Zhejiang University Science B, 2009, 10(10): 740~747.

@article{title="Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane",
author="Xing TAO, Ling-qiao LU, Qing XU, Shu-ren LI, Mao-tsun LIN",
journal="Journal of Zhejiang University Science B",
volume="10",
number="10",
pages="740~747",
year="2009",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0920119"
}

%0 Journal Article
%T Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane
%A Xing TAO
%A Ling-qiao LU
%A Qing XU
%A Shu-ren LI
%A Mao-tsun LIN
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 10
%P 740~747
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0920119

TY - JOUR
T1 - Cardioprotective effects of anesthetic preconditioning in rats with ischemia-reperfusion injury: propofol versus isoflurane
A1 - Xing TAO
A1 - Ling-qiao LU
A1 - Qing XU
A1 - Shu-ren LI
A1 - Mao-tsun LIN
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 10
SP - 740
EP - 747
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0920119


Abstract: 
Objective: We compare the cardioprotective effects of anesthetic preconditioning by propofol and/or isoflurane in rats with ischemia-reperfusion injury. Methods: Male adult Wistar rats were subjected to 60 min of anterior descending coronary artery occlusion followed by 120 min of reperfusion. Before the long ischemia, anesthetics were administered twice for 10 min followed by 5 min washout. isoflurane was inhaled at 1 MAC (0.016) in I group, whereas propofol was inhaled intravenously at 37.5 mg/(kg(h) in P group. A combination of isoflurane and propofol was administered simultaneously in I+P group. Results: In control (without anesthetic preconditioning, C group), remarkable myocardial infarction and apoptosis accompanied by an increased level of cardiac troponin T were noted 120 min after ischemia-reperfusion. As compared to those of control group, I and P groups had comparable cardioprotection. In addition, I+P group shares with I and P groups the comparable cardioprotective effects in terms of myocardial infarction and cardiac troponin T elevation. Conclusion: A combination of isoflurane and propofol produced no additional cardioprotection.

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