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CLC number: R656.2

On-line Access: 2018-01-11

Received: 2016-11-23

Revision Accepted: 2017-03-17

Crosschecked: 2017-12-18

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.1 P.65-70


Activity of metalloproteinases and adiponectin in obese patients—a possible factor of incisional hernias after bariatric procedures

Author(s):  Wojciech Szczęsny, Magdalena Kuligowska-Prusińska, Stanisław Dąbrowiecki, Jakub Szmytkowski, Adrian Reśliński, Maciej Słupski

Affiliation(s):  Ludwik Rydygier College of Medicine in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

Corresponding email(s):   bigar@wp.pl

Key Words:  Metalloproteinase, Adiponectin, Obesity, Incisional hernia

Wojciech Szczęsny, Magdalena Kuligowska-Prusińska, Stanisław Dąbrowiecki, Jakub Szmytkowski, Adrian Reśliński, Maciej Słupski. Activity of metalloproteinases and adiponectin in obese patients—a possible factor of incisional hernias after bariatric procedures[J]. Journal of Zhejiang University Science B, 2018, 19(1): 65-70.

@article{title="Activity of metalloproteinases and adiponectin in obese patients—a possible factor of incisional hernias after bariatric procedures",
author="Wojciech Szczęsny, Magdalena Kuligowska-Prusińska, Stanisław Dąbrowiecki, Jakub Szmytkowski, Adrian Reśliński, Maciej Słupski",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Activity of metalloproteinases and adiponectin in obese patients—a possible factor of incisional hernias after bariatric procedures
%A Wojciech Szczęsny
%A Magdalena Kuligowska-Prusińska
%A Stanisław Dąbrowiecki
%A Jakub Szmytkowski
%A Adrian Reśliński
%A Maciej Słupski
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 1
%P 65-70
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600383

T1 - Activity of metalloproteinases and adiponectin in obese patients—a possible factor of incisional hernias after bariatric procedures
A1 - Wojciech Szczęsny
A1 - Magdalena Kuligowska-Prusińska
A1 - Stanisław Dąbrowiecki
A1 - Jakub Szmytkowski
A1 - Adrian Reśliński
A1 - Maciej Słupski
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 1
SP - 65
EP - 70
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600383

Purpose: metalloproteinases are a key component of the pathogenesis of abdominal hernias. obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and non-overweight controls. Materials and methods: The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA). Results: A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group. Conclusions: The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.

肥胖患者体内金属蛋白酶和脂联素的活性-- 肥胖手术后造成切口疝的可能因素

方法:参与实验的人员为进行肥胖手术的患者和不进行肥胖手术的患者,并将他们分为两组:I(体重指数(BMI)≥35 kg/m2,n=40)和II(BMI<25 kg/m2,n=30),并使用酶联免疫吸附实验测定受试人员体内血清中MMP-2、MMP-9、MMP-13和脂联素的浓度.


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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