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Min-tao Zhong


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.4 P.253-262


Effectiveness of omega-3 polyunsaturated fatty acids against microbial pathogens

Author(s):  Warren Chanda, Thomson P. Joseph, Xue-fang Guo, Wen-dong Wang, Min Liu, Miza S. Vuai, Arshad A. Padhiar, Min-tao Zhong

Affiliation(s):  Department of Microbiology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China

Corresponding email(s):   dyzhongmt@163.com

Key Words:  Linolenic acid, Omega-3 fatty acid, Eicosapentaenoic acid (EPA), Docosahexaenoic acid (DHA), Antimicrobial agent, Fatty acid

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Warren Chanda, Thomson P. Joseph, Xue-fang Guo, Wen-dong Wang, Min Liu, Miza S. Vuai, Arshad A. Padhiar, Min-tao Zhong. Effectiveness of omega-3 polyunsaturated fatty acids against microbial pathogens[J]. Journal of Zhejiang University Science B, 2018, 19(1): 253-262.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%A Warren Chanda
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T1 - Effectiveness of omega-3 polyunsaturated fatty acids against microbial pathogens
A1 - Warren Chanda
A1 - Thomson P. Joseph
A1 - Xue-fang Guo
A1 - Wen-dong Wang
A1 - Min Liu
A1 - Miza S. Vuai
A1 - Arshad A. Padhiar
A1 - Min-tao Zhong
J0 - Journal of Zhejiang University Science B
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PB - Zhejiang University Press & Springer
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Microorganisms provide both beneficial and harmful effects to human beings. Beneficial effects come from the symbiotic relationship that exists between humans and microbiota, but then several human illnesses have turned some friendly microbes into opportunistic pathogens, causing several microbial-related diseases. Various efforts have been made to create and utilize antimicrobial agents in the treatment and prevention of these infections, but such efforts have been hampered by the emergence of antimicrobial resistance. Despite extensive studies on drug discovery to alleviate this problem, issues with the toxicity and tolerance of certain compounds and continuous microbial evolution have forced researchers to focus on screening various phytochemical dietary compounds for antimicrobial activity. linolenic acid and its derivatives (eicosapentaenoic acid and docosahexaenoic acid) are fatty acid%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>omega-3 fatty acids that have been studied due to their role in human health, being important for the brain, the eye, the cardiovascular system, and general human growth. However, their utilization as antimicrobial agents has not been widely appreciated, perhaps due to a lack of understanding of antimicrobial mechanisms, toxicity, and route of administration. Therefore, this review focuses on the efficacy, mechanism, and toxicity of fatty acid%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>omega-3 fatty acids as alternative therapeutic agents for treating and preventing diseases associated with pathogenic microorganisms.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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