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CLC number: R542.2+2

On-line Access: 2011-08-02

Received: 2011-06-29

Revision Accepted: 2011-07-04

Crosschecked: 2011-06-29

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.8 P.638-643

10.1631/jzus.B1101007


Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow


Author(s):  Jia-hui Li, Peng Yang, Ai-li Li, Yong Wang, Yuan-nan Ke, Xian-lun Li

Affiliation(s):  Department of Cardiology, China-Japan Friendship Hospital, Beijing 100029, China

Corresponding email(s):   lixianlun@hotmail.com

Key Words:  Liposomal prostaglandin E1 (lipo-PGE1), Reperfusion no-reflow, Myocardial infarction


Jia-hui Li, Peng Yang, Ai-li Li, Yong Wang, Yuan-nan Ke, Xian-lun Li. Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow[J]. Journal of Zhejiang University Science B, 2011, 12(8): 638-643.

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author="Jia-hui Li, Peng Yang, Ai-li Li, Yong Wang, Yuan-nan Ke, Xian-lun Li",
journal="Journal of Zhejiang University Science B",
volume="12",
number="8",
pages="638-643",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1101007"
}

%0 Journal Article
%T Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow
%A Jia-hui Li
%A Peng Yang
%A Ai-li Li
%A Yong Wang
%A Yuan-nan Ke
%A Xian-lun Li
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 8
%P 638-643
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1101007

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T1 - Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow
A1 - Jia-hui Li
A1 - Peng Yang
A1 - Ai-li Li
A1 - Yong Wang
A1 - Yuan-nan Ke
A1 - Xian-lun Li
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 8
SP - 638
EP - 643
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1101007


Abstract: 
Objective: To evaluate whether liposomal prostaglandin E1 (lipo-PGE1) can decrease reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction (AMI). Methods: Twenty-two male Chinese mini-swines were randomized into three groups: six in a sham-operation group, and eight each in the control and lipo-PGE1 groups. The distal part of the left anterior descending coronary artery (LAD) in the latter two groups was completely occluded for 2 h, and then reperfused for 3 h. Lipo-PGE1 (1 μg/kg) was injected 10 min before LAD occlusion until reperfusion for 1 h in the lipo-PGE1 group. Hemodynamic data and proinflammatory cytokines were examined before AMI, 2 h after occlusion, and 1, 2, and 3 h after reperfusion. Myocardial contrast echocardiography (MCE) and double staining were performed to evaluate the myocardial no-reflow area (NRA). Results: Left ventricular systolic pressure and end-diastolic pressure significantly improved in the lipo-PGE1 group after reperfusion compared with the control group and also 2 h after AMI (P<0.05 for both). MCE and double staining both showed that lipo-PGE1 decreased reperfusion NRA after AMI (P<0.05, P<0.01). Lipo-PGE1 decreased serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) after myocardial infarction reperfusion (P<0.05 for both). Conclusions: Lipo-PGE1 is cardioprotective in our porcine model of myocardial infarction reperfusion no-reflow, decreasing NRA and attenuating the inflammatory response.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Fozzard, H.A., 1975. Validity of myocardial infarction models. Circulation, 52(6 Suppl.):III131-III146.

[2]He, Z.F., Li, Z.J., 2004. Prostaglandin E1 reduces reperfusion injury of myocardium by inhibiting cytokines production during cardiac surgery. J. Zhejiang Univ. (Med. Sci.), 33(4):353-356 (in Chinese).

[3]Jaffe, R., Charron, T., Puley, G., Dick, A., Strauss, B.H., 2008. Microvascular obstruction and the no-reflow phenomenon after percutaneous coronary intervention. Circulation, 117(24):3152-3156.

[4]Kawamura, T., Nara, N., Kadosaki, M., Inada, K., Endo, S., 2000. Prostaglandin E1 reduces myocardial reperfusion injury by inhibiting proinflammatory cytokines production during cardiac surgery. Crit. Care Med., 28(7):2201-2208.

[5]Krombach, G.A., Kinzel, S., Mahnken, A.H., Gunther, R.W., Buecker, A., 2005. Minimally invasive close-chest method for creating reperfused or occlusive myocardial infarction in swine. Invest. Radiol., 40(1):14-18.

[6]Morishima, I., Sone, T., Okumura, K., Tsuboi, H., Kondo, J., Mukawa, H., Matsui, H., Toki, Y., Ito, T., Hayakawa, T., 2000. Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction. J. Am. Coll. Cardiol., 36(4):1202-1209.

[7]Reffelmann, T., Sensebat, O., Birnbaum, Y., Stroemer, E., Hanrath, P., Uretsky, B.F., Schwarz, E.R., 2004. A novel minimal-invasive model of chronic myocardial infarction in swine. Coronary Artery Dis., 15(1):7-12.

[8]Smalling, R.W., Feld, S., Ramanna, N., Amirian, J., Felli, P., Vaughn, W.K., Swenson, C., Janoff, A., 1995. Infarct salvage with liposomal prostaglandin E1 administered by intravenous bolus immediately before reperfusion in a canine infarction-reperfusion model. Circulation, 92(4):935-943.

[9]Suzuki, Y., Lyons, J.K., Yeung, A.C., Ikeno, F., 2008. In vivo porcine model of reperfused myocardial infarction: in situ double staining to measure precise infarct area/area at risk. Catheter Cardiovasc. Interv., 71(1):100-107.

[10]Wang, J.A., Luo, R.H., Zhang, X., Xie, X.J., Hu, X.Y., He, A.N., Chen, J., Li, J.H., 2006. Bone marrow mesenchymal stem cell transplantation combined with perindopril treatment attenuates infarction remodeling in a rat model of acute myocardial infarction. J. Zhejiang Univ.-Sci. B, 7(8):641-647.

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